This fight is very similar to the basic Luminox battle.
Luminox Prime emotes "Luminox rends the space around you, separating the light from the dark!", creating inimical black globules and neutral gold globules throughout the room. Avoid the black globules.
Like Luminox, Luminox Prime launches "Manaetic Missile's Manaetic Explosion", which does enormous damage. The missiles move slowly and explode after 10 seconds, run away around the edges of the room until they self destruct.
It will stop every so often, root itself, and fire a straight-line beam attack. Move to the side to avoid this attack.