The first vampire you need to kill will be Ruen T'Dax and he has a buddy with him. Ruen T'Dax is level 36 ^ ^. His location is -7.66, -24.04, 63.29 Copy in the second level of The Tombs of Night. After you finish killing Ruen T'Dax you will get the dark crystal need.
Now you need to head to the path that leads down to the lowest part of The Tombs of Night. Vieya N'Larn is located at the following location -100.30, -24.13, -17.00 Copy . She is a lvl 36 ^ ^ with two friends. After you destroy her you will receive your vial of noble blood.
Now head down the path to The Crypt of T'Haen not the Vengeance one. The Crypt of T'Haen: Vengeance has lvl 45 Triple Up Epic Monsters in it.
Once in The Crypt of T'Haen you will need to find the dark altar. The location of the altar is -108.79, 26.76, -7.54 Copy . It's a lightpost with purple light coming from it. Surrounded by Bloodsworm backbiter's and soldiers. Right click the Lightpost and go back to Laren Jadefire and turn in.